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KMID : 0359920070260050646
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Korean Journal of Nephrology
2007 Volume.26 No. 5 p.646 ~ p.650
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A Case of Successful Third Renal Transplantation Using Rituximab (anti-CD20 Monoclonal Antibody) in a Highly Sensitized Patient
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Moon Su-Jin
Kim Su-Hyun
Yoon Hye-Eun
Kim Yong-Kyun
Choi Bum-Soon
Yang Chul-Woo
Kim Yong-Soo
Bang Byung-Kee
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Abstract
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Rituximab, chimeric murine/human anti-CD20 monoclonal antibody, has been currently used as treatment of follicular non-Hodgkins lymphoma and posttransplantation lymphoproliferative disease. Nowadays, rituximab has also been utilized in the renal transplantation to get over acute rejection in highly sensitized patients. We hereby report a case of successful renal transplantation in a highly sensitized patient, who has been done the 3rd renal transplantation. A 44-year-old male patient admitted for the 3rd renal transplantation. His previous 2 transplantations failed because of acute rejection. We tried plasmapheresis and intravenous immunoglobulin, widely used as pretransplantation management in high risk patients. In addition to these, we applied 2 times of rituximab (375 mg/m2) before transplantation at interval of 1 week. The renal function of the patient has been within the normal range without any evidence of rejection 6 months after transplantation.
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KEYWORD
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Rituximab, Graft rejection, Renal transplantation
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